New anticancer mechanism of traditional Chinese medicine

Prostate cancer is the most common malignancy of the male genitourinary system dieases.

As a classical anticancer prescription, Hedyotis diffusa Willd. (H) and Scutellaria barbata D.Don (S) are ancient anti-cancer Chinese herb medicines. It has a history of more than 100 years, but its function principle and biological active ingredients are not very clear. The team provided evidence that the formula prevented prostate cancer from progressing by keeping cancer cells in the G2 phase of the cell cycle. Moreover, the effect of stalling cancer cells in G2 is achieved not by destroying the cell’s DNA, but by inhibiting the enzymes needed for G2 cell progression. Using the ChIP technique, the team was able to determine how the plants affected these enzymes. (Hnit´╝î 2019)

Su Su Thae Hnit, Mu Yao, Chanlu Xie, Guangbo Ge, Ling Bi, Shenyi Jin, Lijing Jiao, Ling Xu, Lina Long, Hong Nie, Yu Jin, Linda Rogers, Natalka Suchowerska, Matthew Wong, Tao Liu, Paul De Souza, Zhong Li, Qihan Dong,Transcriptional regulation of G2/M regulatory proteins and perturbation of G2/M Cell cycle transition by a traditional Chinese medicine recipe,Journal of Ethnopharmacology,Volume 251,2020,112526,ISSN 0378-8741,